(1) Effects on the liver: The study of the use of swertiamarin for the treatment of acute liver injury in rats caused by D-galactosamine showed that it has liver protection, detoxification, enzyme reduction, hepatosplenomegaly, and enhanced liver area. The phagocytic function of phagocytes. In vivo experiments on rats, it was found that swertiamarin can reduce the damage of toxic substances to the liver, and can also prevent liver damage caused by hypoxia in rats. The swertiamarin ingredient in Swertia has a significant inhibitory effect on liver cancer cells.
(2) Antispasmodic effect: Swertiamarin has inhibitory effects on the autonomous rhythmic activities of isolated ileum, uterus, gallbladder smooth muscle and biliary sphincter, and can fight acetylcholine, histamine and norepinephrine. Excitatory effects of strontium chloride and vasopressin on the above tissues and organs. The experiment also showed that the swertiamarin of S. chinensis directly acted on the intestinal smooth muscle and exhibited an antispasmodic effect. Intravenous injection of swertiamarin can inhibit the autonomous rhythmic activity of small intestine and uterus in rabbits, and the stimulating effect of acetylcholine or pituitrin on these tissues and organs.
(3) The role of analgesia: Studies have shown that swertiamarin can significantly inhibit the central nervous system, with significant analgesic and sedative effects. The analgesic and antispasmodic effects are the pharmacological basis for the treatment of gastrointestinal pain by swertiamarin.
(4) Other effects: Swertiamarin has anti-inflammatory and anti-viral effects; in addition, Swertiamarin is easily absorbed through the skin surface, and after decomposition, it decomposes to produce erythrocentaurin, which can expand capillaries and activate or It promotes the enzyme system of skin cells and enhances the biochemical function of skin cells. It is widely used in Japan to formulate hair regenerating agents.