Formula:Dihydromyricetin 300mg, or as per your formula
Anti Hangover Capsule
Origin of Capsule
Gelatin capsule or HPMC capsule
1#,0#,00# or as your request
Dihydromyricetin (Ampelopsis grossedentata) 300mg, or as per your formula
Up to standard
In bulk,bottle,blister or box
Store in cool and dry places, keep away from strong light.
2 years when properly stored.
What is Dihydromyricetin (DHM)?
Dihydromyricetin (DHM) is a hepatoprotective flavonoid extracted from Hovenia Dulcis, a Japanese raisin tree that's famous in the traditional medicine world. It's been used since the year 659 throughout Japan, China, and Korea as a hangover cure.But Dihydromyricetin didn't come into the spotlight until 2012, when an associate professor from the UCLA School of Medicine–called Jing Liang performed a study that involved mice getting drunk while using DHM–that it became clear that there was real science behind the ingredient.
The Science of Dihydromyricetin
Liang and her research team first tested whether dihydromyricetin blocks the effect alcohol has on GABA and Glutamate neurotransmitters in the brain. Alcohol binds to GABA receptors and activates them, leading to relaxation, slurred speech and impaired motor function (the feeling of being intoxicated). So they paid close attention to any changes in cognitive skills, clumsiness, and loss of coordination through a series of tests.
Researchers injected rats with a dose of alcohol (EtOH) equivalent to a human drinking 20 beers in two hours and the results were quite astounding.
1) Dihydromyricetin prevents intoxication
They first examined the effects of DHM on LORR (Loss of righting reflex) or the time it took rats to flip while being placed in a V-shape cradle. When administered alcohol with DHM or a placebo, the DHM dosed rats had a significantly lower LORR.However, when administered flumazenil a drug that blocks the GABA receptors, all the benefits of DHM were instantly lost. This suggested that DHM works in the same way, by blocking alcohol from activating those receptors and therefore preventing the rats from getting intoxicated, despite the large amounts of alcohol in their blood.
2) Dihydromyricetin accelerates the breakdown of alcohol
The researchers tested the rat's blood at intervals after giving them the equivalent of 15-20 drinks. They found that when given DHM with alcohol, the rats regained their composure within just 5 minutes, versus 70 minutes. But what was happening beneath the surface was even more fascinating. Dihydromyricetin actually increased the activity of liver enzymes ADH and ALDH, which metabolize alcohol and its toxic byproducts faster. We've broken down the basic process involved in the breakdown of alcohol here:
Alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) — help your body metabolize alcohol.When you drink, ADH metabolizes alcohol to acetaldehyde — a highly toxic substance known to cause hangover symptoms.ALDH then metabolizes acetaldehyde to a harmless byproduct called acetate, which is safely flushed out of your body.
When you drink more alcohol than your liver can break down, these alcohol-induced toxins build up and put a significant amount of stress on your body. The longer these toxins linger in your body — the worse you feel the next day. Having an ADH or ALDH enzyme deficiency can worsen the severity of this toxin build up. But luckily, DHM helps speed up this entire process so you can wake up feeling clearer and refreshed.
Researchers gave the rats a choice between a sweetened solution of alcohol or sweetened water. Normally, rats will develop an addiction to alcohol within several months, but studies found that the group of rats given DHM drank significantly less than the group that didn't. Moreover, the rats that were already addicted to alcohol also significantly reduced their alcohol intake when given DHM. Lastly, the rats were put into a maze, and when given alcohol with placebo, they behaved erratically, stumbling around and cowering away from the corners of the maze. These were clear signs of anxiety associated with alcohol withdrawal. But those treated with DHM behaved normally and were as inquisitive as rats given no alcohol at all, exploring different corridors of the maze.
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